MP682PARATHYROIDECTOMY LONGTERM HARD AND SURROGATE OUTCOMES IN MATCHED GROUPS

Surrogate outcomes in neurology, psychiatry, and psychopharmacology

A surrogate outcome can be defined as an outcome that can be observed sooner, at lower cost, or less invasively than the true outcome, and that enables valid inferences about the effect of intervention on the true outcome. There is increasing interest in the use of surrogate outcomes of treatment efficacy measurement in investigational drug trials. However, the significance of surrogate markers...

Surrogate outcomes: a cautionary note.

See related article, pages 1353–1358. Drug development for acute stroke treatments is complex, very expensive, very time-consuming, and frequently disappointing. Surrogate outcome theory states that new therapies for stroke could be evaluated with smaller sample sizes than are required when traditional functional outcome measures are used by using surrogate outcomes in clinical trials. This wou...

Outcomes associated with conventional versus lipid-based formulations of amphotericin B in propensity-matched groups

BACKGROUND Lipid-based formulations of amphotericin B (LF-AMB) are indicated for treatment of invasive fungal infections in patients intolerant to conventional amphotericin B (CAB) or with refractory infections. Physicians still may choose to administer CAB to such patients. We described the use of CAB and LF-AMB in this population and quantified differences in post-amphotericin B length of sta...

COVID-19 Risk Perception and its Related Factors and Outcomes in Vulnerable Groups: A Systematic Review

Longterm outcomes after combat casualty emergency department thoracotomy.

BACKGROUND The incidence, survival, and blood product use after emergency department thoracotomy (EDT) in combat casualties is unknown. STUDY DESIGN We performed a prospective and retrospective observational study of EDT at a combat support hospital in Iraq, evaluating the impact of injury mechanisms, blood product use, mortality, and longterm neurologic outcomes of survivors. RESULTS From ...